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Symbol
Name
ID

Ins2
insulin II
MGI:96573

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Lymphadenopathy	Hepatosplenomegaly	Peritoneal abscess	Autoimmunity
Disease(s) Associated with INS	Lymphadenopathy	Hepatosplenomegaly	Peritoneal abscess	Autoimmunity
pancreatic cancer
type 1 diabetes mellitus

Mouse Phenotypes

immune system phenotype

abnormal T cell proliferation

decreased T cell proliferation

salivary gland inflammation

insulitis

increased leukocyte cell number

abnormal CD8-positive, alpha beta T cell morphology

abnormal microglial cell morphology

decreased susceptibility to autoimmune diabetes

increased susceptibility to autoimmune diabetes

decreased anti-insulin autoantibody level

increased anti-insulin autoantibody level

abnormal response to transplant

Availability

Mouse Genotype

Ins1^tm1Jja/Ins1^tm1Jja

Ins2^C95S/Ins2^C95S

Ins2^tm1Jja/Ins2^tm1Jja

Tg(H2-Ea-Ins2)1Wehi/Tg(H2-Ea-Ins2)1Wehi

*

Ins2^Akita/Ins2⁺

Ins2^C95S/Ins2⁺

Tg(H2-Ea-Ins2)1Wehi/0

*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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